TY - JOUR T1 - Pseudohyperaldosteroism during itraconazole treatment: a hitherto neglected clinically significant side effect JF - BMJ Case Reports JO - BMJ Case Reports DO - 10.1136/bcr-2021-243191 VL - 14 IS - 6 SP - e243191 AU - Sandra L Brandi AU - Claus L Feltoft AU - Jørgen Serup AU - Ebbe Eldrup Y1 - 2021/06/01 UR - http://casereports.bmj.com/content/14/6/e243191.abstract N2 - We describe a married couple who both presented with hypertension and hypokalaemia. Both patients were diagnosed with pseudohyperaldosteronism triggered by the widely used antifungal drug itraconazole. This effect appears to be dose-dependent, where a daily intake of 100 mg itraconazole is enough to induce pseudohyperaldosteronism. Clinicians should be aware of pseudohyperaldosteronism as a possible adverse effect of itraconazole, and we recommend monitoring potassium levels and blood pressure in all patients receiving this drug over a longer period of time. Voriconazole is probably an alternative antifungal treatment to itraconazole but also with this drug potassium levels should be monitored. ER -