RT Journal Article
SR Electronic
T1 Sarcoid-like reaction: a unique response to immunotherapy in malignant melanoma
JF BMJ Case Reports
JO BMJ Case Reports
FD BMJ Publishing Group Ltd
SP e243723
DO 10.1136/bcr-2021-243723
VO 14
IS 5
A1 Khalid, Taha
A1 Patel, Asma
A1 Ahmed, Alina
A1 Yousif, Ala
YR 2021
UL http://casereports.bmj.com/content/14/5/e243723.abstract
AB In recent years, immunotherapy has revolutionised the treatment landscape for oncology patients with improved survival rates in cancers which previously had a dismissal prognosis. These agents target specific pathways of inhibition such as programmed cell death -1 (PD-1), PD ligand-1 and cytotoxic T-lymphocyte-associated antigen 4 resulting in stimulation of T cell activity. This results in enabling an individual’s own immune system to fight against cancer, a different modality of treatment when compared with traditional chemotherapy. While attacking the tumour cells, there is an increased chance of host tissue immune reactions.We report a case of a patient who received immunotherapy for metastatic malignant melanoma. During the course of the treatment, development of a sarcoid-like reaction was histologically confirmed in the mediastinal lymph nodes. The patient had no respiratory symptoms and continued on the immunotherapy treatment with good clinical and radiological response.