PT  - JOURNAL ARTICLE
AU  - Khalid, Taha
AU  - Patel, Asma
AU  - Ahmed, Alina
AU  - Yousif, Ala
TI  - Sarcoid-like reaction: a unique response to immunotherapy in malignant melanoma
AID  - 10.1136/bcr-2021-243723
DP  - 2021 May 01
TA  - BMJ Case Reports
PG  - e243723
VI  - 14
IP  - 5
4099  - http://casereports.bmj.com/content/14/5/e243723.short
4100  - http://casereports.bmj.com/content/14/5/e243723.full
SO  - BMJ Case Reports2021 May 01; 14
AB  - In recent years, immunotherapy has revolutionised the treatment landscape for oncology patients with improved survival rates in cancers which previously had a dismissal prognosis. These agents target specific pathways of inhibition such as programmed cell death -1 (PD-1), PD ligand-1 and cytotoxic T-lymphocyte-associated antigen 4 resulting in stimulation of T cell activity. This results in enabling an individual’s own immune system to fight against cancer, a different modality of treatment when compared with traditional chemotherapy. While attacking the tumour cells, there is an increased chance of host tissue immune reactions.We report a case of a patient who received immunotherapy for metastatic malignant melanoma. During the course of the treatment, development of a sarcoid-like reaction was histologically confirmed in the mediastinal lymph nodes. The patient had no respiratory symptoms and continued on the immunotherapy treatment with good clinical and radiological response.