PT - JOURNAL ARTICLE AU - Catherine Stauffer AU - Daniel A Llano AU - Suzanna Kitten TI - Nicotinic ganglionic acetylcholine receptor autoantibodies associated with paraneoplastic disease in a neuropsychiatric patient AID - 10.1136/bcr-2020-240824 DP - 2021 May 01 TA - BMJ Case Reports PG - e240824 VI - 14 IP - 5 4099 - http://casereports.bmj.com/content/14/5/e240824.short 4100 - http://casereports.bmj.com/content/14/5/e240824.full SO - BMJ Case Reports2021 May 01; 14 AB - Nicotinic ganglionic acetylcholine receptor autoantibodies (alpha-3-AChR Ab) are associated with paraneoplastic syndromes when present in low elevations. These antibodies can be tested for as part of an autoimmune encephalopathy panel in neuropsychiatric patients; a mildly elevated titre of alpha-3-AChR Ab that may start as an incidental finding can lead to the diagnosis of a previously undetected cancer. While alpha-3-AChR Ab are most typically associated with thymomas and small cell lung cancer, the presence of these antibodies can suggest a diverse range of other cancers. This case presents a patient with longstanding neuropsychiatric symptoms and possible functional hypothyroidism for whom a low elevation in alpha-3-AChR Ab led to the finding of papillary thyroid carcinoma.