RT Journal Article
SR Electronic
T1 Diagnosis and management of a metastatic mixed gestational trophoblastic neoplasia with synchronous primary lung cancer
JF BMJ Case Reports
JO BMJ Case Reports
FD BMJ Publishing Group Ltd
SP e240606
DO 10.1136/bcr-2020-240606
VO 14
IS 5
A1 Iyengar, Varun
A1 Mistry, Hetal
A1 Hibbitt, Catherine
A1 Shimanovsky, Alexei
YR 2021
UL http://casereports.bmj.com/content/14/5/e240606.abstract
AB Mixed gestational trophoblastic neoplasias (GTNs) are rare placental tumours that arise from abnormal fertilisation events. To date, only 34 patients with mixed GTNs have been reported in the literature. As such, the management of such cases remains challenging. This report presents a case of a mixed GTN that was further complicated by a synchronous primary lung adenocarcinoma. Our patient was initially treated with hysterectomy, with surveillance labwork showing persistence of her malignancy. She then began combination chemotherapy, at the end of which she appeared to be in remission clinically. Unfortunately, subsequent imaging showed the persistence of pulmonary nodules that were ultimately resected, demonstrating a new primary lung adenocarcinoma. At present, she remains free of both cancers 2 years after her initial diagnosis. The complexity of this case underscores the importance of patient-centred treatment for rare tumours and the role of a multidisciplinary team in the effort to provide holistic care.