PT  - JOURNAL ARTICLE
AU  - Iyengar, Varun
AU  - Mistry, Hetal
AU  - Hibbitt, Catherine
AU  - Shimanovsky, Alexei
TI  - Diagnosis and management of a metastatic mixed gestational trophoblastic neoplasia with synchronous primary lung cancer
AID  - 10.1136/bcr-2020-240606
DP  - 2021 May 01
TA  - BMJ Case Reports
PG  - e240606
VI  - 14
IP  - 5
4099  - http://casereports.bmj.com/content/14/5/e240606.short
4100  - http://casereports.bmj.com/content/14/5/e240606.full
SO  - BMJ Case Reports2021 May 01; 14
AB  - Mixed gestational trophoblastic neoplasias (GTNs) are rare placental tumours that arise from abnormal fertilisation events. To date, only 34 patients with mixed GTNs have been reported in the literature. As such, the management of such cases remains challenging. This report presents a case of a mixed GTN that was further complicated by a synchronous primary lung adenocarcinoma. Our patient was initially treated with hysterectomy, with surveillance labwork showing persistence of her malignancy. She then began combination chemotherapy, at the end of which she appeared to be in remission clinically. Unfortunately, subsequent imaging showed the persistence of pulmonary nodules that were ultimately resected, demonstrating a new primary lung adenocarcinoma. At present, she remains free of both cancers 2 years after her initial diagnosis. The complexity of this case underscores the importance of patient-centred treatment for rare tumours and the role of a multidisciplinary team in the effort to provide holistic care.