RT Journal Article SR Electronic T1 Vanishing lung syndrome: a consequence of mixed tobacco and marijuana use JF BMJ Case Reports JO BMJ Case Reports FD BMJ Publishing Group Ltd SP e239255 DO 10.1136/bcr-2020-239255 VO 14 IS 5 A1 Salley, Jordan R A1 Kukkar, Vishal A1 Felde, Lanna YR 2021 UL http://casereports.bmj.com/content/14/5/e239255.abstract AB Idiopathic giant bullous emphysema or vanishing lung syndrome (VLS) is a rare, chronic radiological diagnosis characterised by giant emphysematous bullae located primarily in the upper lobes of the lungs. This highly morbid phenotype of chronic obstructive pulmonary disease leads to severe progressive dyspnoea and significant disability. Here, we describe a 48-year-old man with a history significant for long-term tobacco and cannabis smoking, who is found to have VLS. We present a review of recent findings on the association between VLS and the additive effect of marijuana and tobacco.