PT - JOURNAL ARTICLE AU - Jordan R Salley AU - Vishal Kukkar AU - Lanna Felde TI - Vanishing lung syndrome: a consequence of mixed tobacco and marijuana use AID - 10.1136/bcr-2020-239255 DP - 2021 May 01 TA - BMJ Case Reports PG - e239255 VI - 14 IP - 5 4099 - http://casereports.bmj.com/content/14/5/e239255.short 4100 - http://casereports.bmj.com/content/14/5/e239255.full SO - BMJ Case Reports2021 May 01; 14 AB - Idiopathic giant bullous emphysema or vanishing lung syndrome (VLS) is a rare, chronic radiological diagnosis characterised by giant emphysematous bullae located primarily in the upper lobes of the lungs. This highly morbid phenotype of chronic obstructive pulmonary disease leads to severe progressive dyspnoea and significant disability. Here, we describe a 48-year-old man with a history significant for long-term tobacco and cannabis smoking, who is found to have VLS. We present a review of recent findings on the association between VLS and the additive effect of marijuana and tobacco.