PT  - JOURNAL ARTICLE
AU  - Masahiro Taniguchi
AU  - Gota Sudo
AU  - Yuzufumi Sekiguchi
AU  - Hiroshi Nakase
TI  - Autoimmune gastritis concomitant with gastric adenoma and subacute combined degeneration of the spinal cord
AID  - 10.1136/bcr-2021-242836
DP  - 2021 May 01
TA  - BMJ Case Reports
PG  - e242836
VI  - 14
IP  - 5
4099  - http://casereports.bmj.com/content/14/5/e242836.short
4100  - http://casereports.bmj.com/content/14/5/e242836.full
SO  - BMJ Case Reports2021 May 01; 14
AB  - A 62-year-old woman was referred to our department for further investigation of anaemia. Blood test showed macrocytic anaemia. Oesophagogastroduodenoscopy (OGD) revealed proximal-predominant gastric atrophy and flat elevated lesion in the gastric body. Several days after OGD, she complained of gait disturbance and was diagnosed with subacute combined degeneration of the spinal cord. Furthermore, laboratory tests showed positive for both anti-parietal cell and anti-intrinsic factor antibodies, as well as increased serum gastrin level and decreased pepsinogen I level, which confirmed the diagnosis of autoimmune gastritis (AIG). Anaemia and neurological symptoms were improved after vitamin B12 supplementation. Subsequently, the patient underwent gastric endoscopic submucosal dissection; histopathological examination revealed gastric adenoma. AIG can cause gastric neoplasms and vitamin B12 deficiency, with the latter resulting in pernicious anaemia and neurological disorders. These diseases are treatable but potentially life-threatening. This case highlights the importance of early diagnosis of AIG and proper management of its comorbidities.