%0 Journal Article %A Jill M Krapf %A Rachel K Casey %A Andrew T Goldstein %T Reactive non-sexually related acute genital ulcers associated with COVID-19 %D 2021 %R 10.1136/bcr-2021-242653 %J BMJ Case Reports %P e242653 %V 14 %N 5 %X Acute genital ulcers (AGU), known as Lipschütz ulcers, are painful vulvar ulcers typically affecting non-sexually active girls and women. AGU have been associated with viral infections, namely, Epstein-Barr virus (EBV). Here, we describe a case of AGU in the setting of SARS-CoV-2 in a non-sexually active adolescent girl hospitalised for pain control and urinary retention, who failed a course of oral corticosteroids and then improved with colchicine. Testing for herpes simplex virus, EBV and Behcet’s syndrome were all negative. Testing for SARS-CoV-2 was positive. COVID-19 increases cytokines such as tumour necrosis factor alpha, which has been shown to affect endothelial cell adhesion and neutrophil chemotaxis, leading to aphthosis. %U https://casereports.bmj.com/content/bmjcr/14/5/e242653.full.pdf