PT  - JOURNAL ARTICLE
AU  - Benjamin Ayeboa-Sallah
AU  - Saad Qutab
AU  - Richard Grace
AU  - Neel Sharma
TI  - Rare case of plasmablastic myeloma diagnosed on lung biopsy
AID  - 10.1136/bcr-2020-240998
DP  - 2021 Mar 01
TA  - BMJ Case Reports
PG  - e240998
VI  - 14
IP  - 3
4099  - http://casereports.bmj.com/content/14/3/e240998.short
4100  - http://casereports.bmj.com/content/14/3/e240998.full
SO  - BMJ Case Reports2021 Mar 01; 14
AB  - Plasmablastic myeloma is a rare variant of multiple myeloma characterised by neoplastic proliferation of single clone of plasma cells producing monoclonal immunoglobulins. A 60-year-old man presented to hospital with a 6-week history of chest pain, back pain, leg weakness and numbness. Imaging revealed a 75 mm left lobular lung mass with chest wall invasion, metastatic bony and soft-tissue deposits and spinal cord compression at T5 level. Lung biopsy, for suspected metastatic lung cancer, surprisingly showed features of plasmablastic myeloma. Protein electrophoresis demonstrated 2 g/L of IgG lambda paraproteinaemia and an increase in lambda light chains with reduced kappa/lambda ratio of 0.01. Bone marrow biopsy did not show evidence of infiltration by disease. The patient received radiotherapy to the spine; responded to third-line chemotherapy and received autologous stem cell transplant. This case adds to the rare causes of lung mass and is the first reported case of plasmablastic myeloma diagnosed on lung biopsy.