PT  - JOURNAL ARTICLE
AU  - Nuwan Dhanushka Miththinda Jasenthu Kankanamage
AU  - James Gome
TI  - Successful thrombolysis of normotensive pulmonary embolism with life-threatening hypoxia in a young man with Klinefelter syndrome
AID  - 10.1136/bcr-2020-240118
DP  - 2021 Feb 01
TA  - BMJ Case Reports
PG  - e240118
VI  - 14
IP  - 2
4099  - http://casereports.bmj.com/content/14/2/e240118.short
4100  - http://casereports.bmj.com/content/14/2/e240118.full
SO  - BMJ Case Reports2021 Feb 01; 14
AB  - Klinefelter syndrome (KS) affects males born with an additional X chromosome giving the genotype 47XXY classically. This syndrome has primary features of infertility and hypogonadism along with other features including a genetically hypercoagulable state. When associated with other risk factors, KS further increases the risk of venous thromboembolism and could result in life-threatening pulmonary embolism (PE). There should be a lower threshold in suspecting PE as a cause of acute respiratory failure in this patient group and thrombolysis should be considered early in normotensive PE with severe hypoxia for best patient outcomes. Furthermore, clinicians should be cautious in managing testosterone therapy in patients with KS and additional thromboembolic risk factors.