TY - JOUR T1 - Type-5 Bartter syndrome presenting with metabolic seizure in adulthood JF - BMJ Case Reports JO - BMJ Case Reports DO - 10.1136/bcr-2020-235349 VL - 14 IS - 2 SP - e235349 AU - Aqeel Hussain AU - Mahendra Atlani AU - Abhishek Goyal AU - Alkesh Kumar Khurana Y1 - 2021/02/01 UR - http://casereports.bmj.com/content/14/2/e235349.abstract N2 - Bartter syndrome is a very rare and heterogeneous disease with variable age of onset and symptom severity. Genotypically they have inherited disorders of the thick ascending limb in the renal tubular system, which manifest phenotypically as electrolyte imbalance due to loss of sodium, chloride and potassium. Gain of function mutations in the calcium-sensing receptor has been described in some patients with Bartter’s syndrome (type-5 Bartter syndrome or autosomal dominant hypocalcaemia with Bartter syndrome) associated with hypocalcaemia and hypercalciuria differentiating it from Gitelman syndrome. This phenotype has been reported to present in adulthood with metabolic abnormalities. We present a case of a middle-aged woman who presented with metabolic seizures and on evaluation was found to have profound electrolyte abnormalities which were corrected with supplements and led to the resolution of symptoms. ER -