PT - JOURNAL ARTICLE AU - Carl-Joe Mehanna AU - Lea Kallassi AU - Ahmad M Mansour AU - Rola N Hamam TI - <em>Streptococcus salivarius</em> endogenous endophthalmitis AID - 10.1136/bcr-2020-239299 DP - 2021 Feb 01 TA - BMJ Case Reports PG - e239299 VI - 14 IP - 2 4099 - http://casereports.bmj.com/content/14/2/e239299.short 4100 - http://casereports.bmj.com/content/14/2/e239299.full SO - BMJ Case Reports2021 Feb 01; 14 AB - We describe a case of endogenous endophthalmitis in an elderly man caused by Streptococcus salivarius. An 88-year-old male patient with diabetes with iron deficiency anaemia and history of transcatheter aortic valve implantation presented with an insidious clinical picture of atraumatic endophthalmitis. No internal or external source could be identified. Diagnostic and therapeutic vitrectomy revealed papillomacular abscess and vitreous fluids grew S. salivarius. Despite lack of an identifiable source of infection, a high index of suspicion for atypical presentations is required in patients with multiple comorbidities that could weaken their immune system towards opportunistic infections. Early detection, microbiological evaluation and prompt treatment are critical to avoid disastrous outcomes. While S. salivarius has been implicated in cases of exogenous endophthalmitis, this is the first reported case of endogenous endophthalmitis due to S. salivarius.