PT - JOURNAL ARTICLE AU - Catarina Mira AU - Pedro Montalvão AU - Isabel Fonseca AU - Alexandra Borges TI - Localised laryngotracheal amyloidosis: a differential diagnosis not to forget AID - 10.1136/bcr-2020-237954 DP - 2021 Feb 01 TA - BMJ Case Reports PG - e237954 VI - 14 IP - 2 4099 - http://casereports.bmj.com/content/14/2/e237954.short 4100 - http://casereports.bmj.com/content/14/2/e237954.full SO - BMJ Case Reports2021 Feb 01; 14 AB - We present a case of multifocal laryngotracheal amyloidosis (LTA) in a 43-year-old man with persistent and progressive dysphonia and dyspnoea, and a first inconclusive histology. Although laryngeal amyloidosis accounts for fewer than 1% of all benign laryngeal tumours, it is in fact the most common site of amyloid deposition in the head, neck and respiratory tract. The clinical scenario is non-specific and diagnosis depends on a high degree of suspicion and on histology. Imaging is useful in mapping lesions, which are often more extensive than they appear during laryngoscopy. Despite being a benign entity, the prognosis is variable with a high-rate and long-latency recurrences, requiring long-term follow-up.