PT - JOURNAL ARTICLE AU - Hashim, Maram AU - Athar, Syed AU - Gaba, Waqar Haider TI - New onset adrenal insufficiency in a patient with COVID-19 AID - 10.1136/bcr-2020-237690 DP - 2021 Jan 01 TA - BMJ Case Reports PG - e237690 VI - 14 IP - 1 4099 - http://casereports.bmj.com/content/14/1/e237690.short 4100 - http://casereports.bmj.com/content/14/1/e237690.full SO - BMJ Case Reports2021 Jan 01; 14 AB - SARS-CoV-2 is the cause of COVID-19. Since the outbreak and rapid spread of COVID-19, it has been apparent that the disease is having multi-organ system involvement. Still its effect in the endocrine system is not fully clear and data on cortisol dynamics in patients with COVID-19 are not yet available. SARS-CoV-2 can knock down the host’s cortisol stress response. Here we present a case of a 51-year-old man vomiting for 10 days after having confirmed COVID-19 infection. He had hypotension and significant hyponatraemia. Work-up was done including adrenocorticotropic hormone stimulation test. He was diagnosed as suffering from adrenal insufficiency and started on steroids with subsequent improvement in both blood pressure and sodium level. COVID-19 can cause adrenal insufficiency. Clinicians must be vigilant about the possibility of an underlying relative cortisol deficiency in patients with COVID-19.