PT  - JOURNAL ARTICLE
AU  - Jose Maciel Larios
AU  - Jordan Ciuro
AU  - Thomson Sam Varghese
AU  - Susan Elizabeth Lyons
TI  - Successful treatment of dermato-neuro syndrome with plasmapheresis
AID  - 10.1136/bcr-2020-237170
DP  - 2020 Dec 01
TA  - BMJ Case Reports
PG  - e237170
VI  - 13
IP  - 12
4099  - http://casereports.bmj.com/content/13/12/e237170.short
4100  - http://casereports.bmj.com/content/13/12/e237170.full
SO  - BMJ Case Reports2020 Dec 01; 13
AB  - Altered mental status can have many causes ranging from emergent intracranial pathologies to more insidious, systemic toxic aetiologies. We report a rare case of dermato-neuro syndrome in a 71-year-old man with a known history of scleromyxoedema. The patient initially presented with encephalopathy which quickly progressed to generalised tonic–clonic seizures and coma. While his presentation fits with other, although rare, cases of dermato-neuro syndrome, it is imperative to rule out lethal, more common causes of altered mentation. Due to the rarity and difficulty in diagnosis of dermato-neuro syndrome, there is a significant debate regarding the optimal management as there are no standardised treatment protocols. In our case, the patient was successfully treated with plasmapheresis resulting in improved neurologic function.