RT Journal Article SR Electronic T1 Radiation-induced sarcoma presenting as a gluteal abscess: a diagnostic and therapeutic challenge JF BMJ Case Reports JO BMJ Case Reports FD BMJ Publishing Group Ltd SP e236601 DO 10.1136/bcr-2020-236601 VO 13 IS 12 A1 Sudharshan Mahalingam A1 Sudharsanan Sundaramurthi A1 Balamourougan Krishnaraj A1 Sarath Chandra Sistla YR 2020 UL http://casereports.bmj.com/content/13/12/e236601.abstract AB Sarcomas are a rare and fatal treatment complication following radiotherapy. Radiation-induced sarcomas (RISs) presenting as a gluteal abscess is a rarity, accounting for its varied presentation. We present a case of a middle-aged woman, post-chemo-radiation for carcinoma cervix 5 years ago, who presented with gluteal abscess. Achieving haemostasis post incision and drainage under anaesthesia was a challenge. On further evaluation, she was diagnosed with radiation-induced gluteal soft tissue sarcoma. Haemostasis was achieved after radiation following failed attempts of surgical and radiological interventions. She is currently planned for chemotherapy. Cancer survivors have an increased risk of developing a second malignancy following radiation treatment. RISs are highly aggressive, exhibit a varied clinical presentation and pose a challenge in early diagnosis; thus, have a poor outcome. RISs pose a diagnostic challenge; any dubious lesion in the previously irradiated field should raise suspicion and prompt aggressive management.