RT Journal Article
SR Electronic
T1 Voltage-gated potassium channel limbic encephalitis presenting as functional cognitive impairment
JF BMJ Case Reports
JO BMJ Case Reports
FD BMJ Publishing Group Ltd
SP e233179
DO 10.1136/bcr-2019-233179
VO 13
IS 12
A1 Eric Garrels
A1 Fawziya Huq
A1 Gavin McKay
YR 2020
UL http://casereports.bmj.com/content/13/12/e233179.abstract
AB Limbic encephalitis is often reported to present as seizures and impaired cognition with little focus on psychiatric presentations. In this case report, we present a 49-year-old man who initially presented to the Psychiatric Liaison Service with a several month history of confusion with the additional emergence of visual hallucinations and delusions. Due to the inconsistent nature of the symptoms in the context of a major financial stressor, a provisional functional cognitive impairment diagnosis was made. Investigations later revealed a positive titre of voltage-gated potassium channel (VGKC) antibodies, subtype leucine-rich glioma inactivated 1 accounting for his symptoms which dramatically resolved with steroids and immunoglobulins. This case highlighted the need for maintaining broad differential diagnoses in a patient presenting with unusual psychiatric symptoms.