RT Journal Article SR Electronic T1 Pancreatic mesothelial cyst JF BMJ Case Reports JO BMJ Case Reports FD BMJ Publishing Group Ltd SP e236255 DO 10.1136/bcr-2020-236255 VO 13 IS 10 A1 Charbel Chater A1 Joseph Obeid Obeid A1 Seba Mhanna YR 2020 UL http://casereports.bmj.com/content/13/10/e236255.abstract AB A 60-year-old woman was investigated for abdominal pain and increasing asthenia. Abdominal CT revealed a 25 mm hypodense cystic lesion in the tail of the pancreas. MRI showed a multiloculated cystic lesion, T1-hypointense and T2-hyperintense lesion, without wall enhancement. Endoscopic ultrasound detected a 25 mm multi-loculated cystic lesion, with regular margin and without pancreatic duct communication. Diagnosis of pancreatic mucinous cystadenoma was discussed and the patient was referred to surgery. She underwent distal pancreatectomy with spleen preservation. Pathological examination revealed the diagnosis of pancreatic mesothelial cyst. Histologically, the cyst was multiloculated, lined by cuboidal epithelium, ovoid nuclei and amphophilic cytoplasm, without mucin deposition or cytological atypia. Immunohistochemistry examination revealed positive staining for cytokeratin 5/6, vimentin and calretinin. At 1-year follow-up, she is in her usual health, without any symptoms.