TY - JOUR T1 - Severe hyperthermia due to oral baclofen withdrawal JF - BMJ Case Reports JO - BMJ Case Reports DO - 10.1136/bcr-2020-234710 VL - 13 IS - 9 SP - e234710 AU - Vishesh Paul AU - Kari Righter AU - Elise Kim AU - Weston Nadherny Y1 - 2020/09/01 UR - http://casereports.bmj.com/content/13/9/e234710.abstract N2 - We report a case of a 53-year-old woman who presented initially with sepsis and later in her stay developed a severe and rapidly progressing hyperthermia after a decrease in oral baclofen dosage. Her fever peaked at 42.5○C (108.5○F), creating a broad differential diagnosis and complicating her initial sepsis diagnosis. When the oral baclofen dose was increased, the fevers resolved which confirmed the clinical diagnosis of baclofen withdrawal. Dose reductions of oral baclofen should be made gradually and with caution, and patients should be monitored for fevers as a possible symptom of baclofen withdrawal. ER -