TY - JOUR T1 - Clinical case of the neoadjuvant treatment with nivolumab in a patient with microsatellite unstable (MSI-H) locally advanced gastric cancer JF - BMJ Case Reports JO - BMJ Case Reports DO - 10.1136/bcr-2020-236144 VL - 13 IS - 9 SP - e236144 AU - Viacheslav Chubenko AU - Gamzat Inusilaev AU - Evgeny Imyanitov AU - Vladimir Moiseyenko Y1 - 2020/09/01 UR - http://casereports.bmj.com/content/13/9/e236144.abstract N2 - Locally advanced gastric cancer (GC) is often managed by neoadjuvant chemotherapy and surgery; however, pathological complete responses to preoperative systemic treatment are rare. Some GCs are characterised by high-level microsatellite instability (MSI-H) and therefore are potentially sensitive to anti-PD1 (the programmed death 1) therapy. Neoadjuvant immune checkpoint blockade demonstrated promising results in a number of trials involving various categories of patients with cancer; therefore, we considered feasible to offer preoperative nivolumab to a patient with T3N1M0 MSI-H GC. The patient experienced a reduction of the tumour size and the analysis of surgical material revealed complete elimination of tumour cells. MSI-H status deserves to be considered in future trials on patients with GC. ER -