RT Journal Article
SR Electronic
T1 Child with tuberculous meningitis and COVID-19 coinfection complicated by extensive cerebral sinus venous thrombosis
JF BMJ Case Reports
JO BMJ Case Reports
FD BMJ Publishing Group Ltd
SP e238597
DO 10.1136/bcr-2020-238597
VO 13
IS 9
A1 Farida Essajee
A1 Regan Solomons
A1 Pierre Goussard
A1 Ronald Van Toorn
YR 2020
UL http://casereports.bmj.com/content/13/9/e238597.abstract
AB We herein report a case of a child with tuberculous meningitis and COVID-19 coinfection complicated by hydrocephalus, arterial ischaemic stroke and extensive cerebral sinus venous thrombosis. Both conditions induce a proinflammatory cytokine drive resulting, among others, in a prothrombotic state. The disruption of the coagulation system in this case was supported by elevated D-dimers, fibrinogen and ferritin levels, consistent with thrombotic complications reported in some adult patients infected with COVID-19. The child also exhibited prolonged viral shedding that suggests severe disease.