RT Journal Article
SR Electronic
T1 Use of rituximab in lymphomatoid granulomatosis with isolated central nervous system involvement
JF BMJ Case Reports
JO BMJ Case Reports
FD BMJ Publishing Group Ltd
SP e235412
DO 10.1136/bcr-2020-235412
VO 13
IS 9
A1 Jesse Mooneyham
A1 Cesar Gentille
A1 Andrea Barbieri
A1 Shilpan Shah
YR 2020
UL http://casereports.bmj.com/content/13/9/e235412.abstract
AB A 33-year-old woman presented to the emergency room with severe headaches. A CT scan of the head revealed two brain lesions with associated vasogenic oedema. Diagnostic resection of one of the lesions followed by pathological analysis revealed grade III lymphomatoid granulomatosis (LYG). Staging investigations elsewhere in the body were negative, isolating this case of LYG to the central nervous system, an atypical presentation. After the resection, she was treated with single-agent rituximab 375 mg/m2. The follow-up MRI demonstrated the resolution of brain lesions and no progression of the disease.