RT Journal Article SR Electronic T1 Harlequin ichthyosis from birth to 12 years JF BMJ Case Reports JO BMJ Case Reports FD BMJ Publishing Group Ltd SP e235225 DO 10.1136/bcr-2020-235225 VO 13 IS 8 A1 Jemima Heap A1 Mary Judge A1 Beena Padmakumar YR 2020 UL http://casereports.bmj.com/content/13/8/e235225.abstract AB A neonate was born with generalised, erythrodermic, thick, fissured skin, severe ectropion, hypoplastic auricles and limb abnormalities. A clinical diagnosis of harlequin ichthyosis was made, allowing supportive therapies to be commenced promptly. Oral acitretin was initiated on day 3 of life, complemented by an intensive skin care regimen. Rehydration, prevention and treatment of infection, temperature control and nutritional support were all essential to see him through the neonatal period. Nearly 12 years later, this child continues to receive multidisciplinary input and enjoys a good quality of life.