PT  - JOURNAL ARTICLE
AU  - Ravi Masson
AU  - Hooman Bakhshi
AU  - Tariq M Haddad
TI  - Intermittent left bundle branch block and acute heart failure in trastuzumab-induced cardiotoxicity
AID  - 10.1136/bcr-2020-236009
DP  - 2020 Jul 01
TA  - BMJ Case Reports
PG  - e236009
VI  - 13
IP  - 7
4099  - http://casereports.bmj.com/content/13/7/e236009.short
4100  - http://casereports.bmj.com/content/13/7/e236009.full
SO  - BMJ Case Reports2020 Jul 01; 13
AB  - A 70-year-old woman with HER2+/ER+ breast cancer on adjuvant trastuzumab therapy without a history of cardiovascular disease presented with respiratory failure from influenza and was found to have intermittent left bundle branch block (LBBB) with new onset systolic heart failure. Her course was complicated by polymorphic ventricular tachycardia and recurrent chest pain. Significant investigations included a normal cardiac MRI and cardiac catheterisation with unobstructed coronaries. It was determined that the aetiology of her heart failure was trastuzumab-induced cardiotoxicity after comprehensive workup. This case highlights an uncommon presentation of LBBB and the steps taken to diagnose a rare cardiomyopathy.