PT  - JOURNAL ARTICLE
AU  - Nikhil Shah
AU  - Anuradha Khadilkar
AU  - Vaman Khadilkar
AU  - Sagar Lad
TI  - Rare association of Beckwith-Wiedemann syndrome with Hirschsprung’s disease in an infant with hypoglycemia
AID  - 10.1136/bcr-2020-235121
DP  - 2020 Apr 01
TA  - BMJ Case Reports
PG  - e235121
VI  - 13
IP  - 4
4099  - http://casereports.bmj.com/content/13/4/e235121.short
4100  - http://casereports.bmj.com/content/13/4/e235121.full
SO  - BMJ Case Reports2020 Apr 01; 13
AB  - Hypoglycaemic due to congenital hyperinsulinism in Beckwith-Wiedemann syndrome is commonly seen. It is usually transient and is managed by enteral feeds, high glucose-containing intravenous fluids and medications like diazoxide. We describe a case of an infant with genetically proven Beckwith-Wiedemann syndrome with prolonged hyperinsulinemic hypoglycaemia. Despite treatment with high glucose-containing intravenous fluids, diazoxide and octreotide, her hypoglycaemia persisted. In addition to this, she also developed features of intestinal obstruction, which further complicated the management of hypoglycaemia. She underwent a rectal biopsy for this, which was highly suggestive of Hirschprung’s disease. Following surgery, her abdominal distension and feed intolerance were settled and sugar control was improved. We present a rare association of Hirschsprung’s disease with Beckwith-Wiedemann syndrome. To the best of our knowledge, this association has not been previously reported and this added to the difficulty in managing hyperinsulinemic hypoglycaemia in our patient.