RT Journal Article SR Electronic T1 Inherited cause of in utero digital malformations JF BMJ Case Reports JO BMJ Case Reports FD BMJ Publishing Group Ltd SP e232020 DO 10.1136/bcr-2019-232020 VO 13 IS 3 A1 Catherine Gooch A1 Caitlin Wright A1 Katherine Nelson A1 Nathaniel Robin YR 2020 UL http://casereports.bmj.com/content/13/3/e232020.abstract AB Amniotic band sequence (ABS) is common birth defect of incompletely understood origin. Here we describe a case of ABS in a child with paternally inherited Ehlers-Danlos syndrome, vascular type (vEDS). This is the third reported instance of ABS associated with paternally inherited vEDS in the medical literature. The two main theories of ABS formation are the extrinsic and intrinsic. The extrinsic theory states that placental tears form fibrous cords that wrap around the fetus; the intrinsic states that poor vascularisation in the fetus leads to necrosis of distal extremities. We believe this case supports extrinsic theory as it shows that as an amnion weakened by vEDS in fetal components is associated with ABS.