TY - JOUR T1 - Inherited cause of in utero digital malformations JF - BMJ Case Reports JO - BMJ Case Reports DO - 10.1136/bcr-2019-232020 VL - 13 IS - 3 SP - e232020 AU - Catherine Gooch AU - Caitlin Wright AU - Katherine Nelson AU - Nathaniel Robin Y1 - 2020/03/01 UR - http://casereports.bmj.com/content/13/3/e232020.abstract N2 - Amniotic band sequence (ABS) is common birth defect of incompletely understood origin. Here we describe a case of ABS in a child with paternally inherited Ehlers-Danlos syndrome, vascular type (vEDS). This is the third reported instance of ABS associated with paternally inherited vEDS in the medical literature. The two main theories of ABS formation are the extrinsic and intrinsic. The extrinsic theory states that placental tears form fibrous cords that wrap around the fetus; the intrinsic states that poor vascularisation in the fetus leads to necrosis of distal extremities. We believe this case supports extrinsic theory as it shows that as an amnion weakened by vEDS in fetal components is associated with ABS. ER -