RT Journal Article
SR Electronic
T1 Unusual case of adult familial Menetrier disease in siblings
JF BMJ Case Reports
JO BMJ Case Reports
FD BMJ Publishing Group Ltd
SP e231175
DO 10.1136/bcr-2019-231175
VO 12
IS 10
A1 Emily Brownson
A1 Adrian J Stanley
A1 Prakash Konanahalli
A1 John P Seenan
YR 2019
UL http://casereports.bmj.com/content/12/10/e231175.abstract
AB Menetrier disease is a rare disease characterised by hyperplasia of the gastric epithelium and large gastric folds. We present a case of a 58-year-old woman who was referred with iron deficiency anaemia, with a family history of a sibling who had undergone gastrectomy for presumed gastric malignancy. Endoscopy showed prominent gastric mucosal folds and biopsies showed hyperplastic gastric mucosa, with prominent foveolar hyperplasia suggestive of Menetrier disease. Further information about her brother’s diagnosis was sought, and it was found that his pathology after gastrectomy showed diffuse glandular hyperplasia also in keeping with Menetrier disease. Adult familial Menetrier disease has so far been a rarity in the literature—review elicits five previous cases of this presentation in siblings.