PT  - JOURNAL ARTICLE
AU  - Sneha N Patel
AU  - Sai Krishna Koyoda
AU  - Daniel Schwartz
AU  - Bibi Ayesha
TI  - Severe hand pain as an extracardiac manifestation of transthyretin amyloidosis
AID  - 10.1136/bcr-2019-229677
DP  - 2019 Oct 01
TA  - BMJ Case Reports
PG  - e229677
VI  - 12
IP  - 10
4099  - http://casereports.bmj.com/content/12/10/e229677.short
4100  - http://casereports.bmj.com/content/12/10/e229677.full
SO  - BMJ Case Reports2019 Oct 01; 12
AB  - Transthyretin amyloidosis is a multisystemic disease caused by the aggregation of amyloid fibrils, resulting in high morbidity and mortality in the presence of cardiac involvement. Patients often experience vague symptoms that make amyloidosis difficult to diagnose. Differential diagnosis for hand pain in a patient with systemic amyloidosis is broad. We present a patient with severe hand cramping and inability to perform activities of daily living. This preceded a new diagnosis of familial amyloid cardiomyopathy. The patient was a poor responder to systemic corticosteroids, anti-inflammatories and anticonvulsant therapy. Her unique presentation gives insight into a rare but debilitating disorder and the potential link between amyloidosis and other disease processes.