RT Journal Article
SR Electronic
T1 Rosuvastatin-related rhabdomyolysis causing severe proximal paraparesis and acute kidney injury
JF BMJ Case Reports
JO BMJ Case Reports
FD BMJ Publishing Group Ltd
SP e229244
DO 10.1136/bcr-2019-229244
VO 12
IS 10
A1 Kosar Hussain
A1 Anil Xavier
YR 2019
UL http://casereports.bmj.com/content/12/10/e229244.abstract
AB We describe the case of a 76-year-old man who presented with bilateral lower limb weakness associated with decreased urine output. His initial blood results showed acute kidney injury (AKI) stage 3 with substantially raised serum creatine kinase concentration of 37 950 IU/L (normal range <171 U/L). He had been on high-dose rosuvastatin for 4 years with a recent brand change occurring 1 week prior to onset of symptoms. There was no history of pre-existing neuromuscular disease. Statin-related rhabdomyolysis was suspected and rosuvastatin was withheld. His muscle strength gradually improved. He required haemodialysis for 10 weeks. He was discharged home after a complicated course of hospitalisation. His renal function improved and he became dialysis-independent; however, he was left with residual chronic kidney disease.