RT Journal Article
SR Electronic
T1 Rare case of triple mutant (KRAS + NRAS + BRAF) metastatic colon adenocarcinoma
JF BMJ Case Reports
JO BMJ Case Reports
FD BMJ Publishing Group Ltd
SP e221816
DO 10.1136/bcr-2017-221816
VO 12
IS 9
A1 Anusha Vittal
A1 Disha Sharma
A1 Ipsita Samanta
A1 Anup Kasi
YR 2019
UL http://casereports.bmj.com/content/12/9/e221816.abstract
AB KRAS is detected in 30%–50% of colorectal cancer (CRC) and BRAF mutations are found in 10% of CRC. A 62-year-old man with the long-standing smoking history presented to the emergency department with abdominal pain, weight loss and constipation. CT scan of abdomen/pelvis showed obstructive mass which was found to be colon adenocarcinoma which on further molecular analysis tested positive for KRAS, NRAS and BRAF mutations. His tumour progressed despite chemotherapy and surgery and he died within a year of diagnosis. Concomitant KRAS, NRAS and BRAF mutations are rare enough to be considered mutually exclusive but coexistent mutations appear to be a distinct molecular and clinical subset which needs new and effective treatment strategies in a setting of dismal prognosis.