TY - JOUR T1 - Aggressive type of central giant cell granuloma in a woman on hormone replacement therapy: a histopathological insight JF - BMJ Case Reports JO - BMJ Case Reports DO - 10.1136/bcr-2019-230847 VL - 12 IS - 8 SP - e230847 AU - Swati Gautam AU - Meetkamal Grewal AU - Nitin Saini AU - Karandeep Singh Arora Y1 - 2019/08/01 UR - http://casereports.bmj.com/content/12/8/e230847.abstract N2 - Quite a few lesions of the oral cavity specifically of the gingiva have a greater inclination towards women and mostly occur during the first four decades of life, the cause of which may be credited to the changing levels of sex hormones. Out of all such lesions, one lesion whose aetiology is still unclear and which originats from the periosteum or periodontal ligament is central giant cell granuloma. Repeatedly, it is has been described as a reactive lesion, the cause of which may be secondary to local irritants or trauma, specifically plaque or calculus, which is not considered to be a true neoplasm. Here we present a case of a 51-year-old female patient with aggressive gingival growth within 10–13 months of hormonal replacement therapy. The aetiology, histological features and appropriate treatment are discussed in the light of current literature. ER -