RT Journal Article
SR Electronic
T1 Leukemoid reaction: a rare paraneoplastic event in a case of advanced penile cancer and its management
JF BMJ Case Reports
JO BMJ Case Reports
FD BMJ Publishing Group Ltd
SP e230826
DO 10.1136/bcr-2019-230826
VO 12
IS 8
A1 Amit Kumar Mishra
A1 Ketan Mehra
A1 Ramanitharan Manikandan
A1 Lalgudi Narayanan Dorairajan
YR 2019
UL http://casereports.bmj.com/content/12/8/e230826.abstract
AB Leukemoid reaction is a paraneoplastic phenomenon associated predominantly with solid tumours. Malignancies presenting with leukemoid reaction have a grave prognosis. It is defined as persistent neutrophil count greater than 50×103 cells/µL. We report a case of leukemoid reaction in a patient with metastatic penile cancer. A 60-year-old man with partial penectomy status for squamous cell carcinoma of penis on neoadjuvant chemotherapy, presented with left fungating inguinal lymphadenopathy and total leucocyte count 96×103 cells/µL and hypercalcaemia. Leucocytealkaline phosphatase (LAP) score was excessively elevated. The patient underwent left ilioinguinal block dissection along with vastus lateralis flap for defect reconstruction. Postoperatively, the neutrophil counts and serum calcium level normalised. The patient improved clinically and was discharged.