PT - JOURNAL ARTICLE AU - Amit Kumar Mishra AU - Ketan Mehra AU - Ramanitharan Manikandan AU - Lalgudi Narayanan Dorairajan TI - Leukemoid reaction: a rare paraneoplastic event in a case of advanced penile cancer and its management AID - 10.1136/bcr-2019-230826 DP - 2019 Aug 01 TA - BMJ Case Reports PG - e230826 VI - 12 IP - 8 4099 - http://casereports.bmj.com/content/12/8/e230826.short 4100 - http://casereports.bmj.com/content/12/8/e230826.full SO - BMJ Case Reports2019 Aug 01; 12 AB - Leukemoid reaction is a paraneoplastic phenomenon associated predominantly with solid tumours. Malignancies presenting with leukemoid reaction have a grave prognosis. It is defined as persistent neutrophil count greater than 50×103 cells/µL. We report a case of leukemoid reaction in a patient with metastatic penile cancer. A 60-year-old man with partial penectomy status for squamous cell carcinoma of penis on neoadjuvant chemotherapy, presented with left fungating inguinal lymphadenopathy and total leucocyte count 96×103 cells/µL and hypercalcaemia. Leucocytealkaline phosphatase (LAP) score was excessively elevated. The patient underwent left ilioinguinal block dissection along with vastus lateralis flap for defect reconstruction. Postoperatively, the neutrophil counts and serum calcium level normalised. The patient improved clinically and was discharged.