TY - JOUR T1 - Macitentan in the treatment of severe digital ulcers JF - BMJ Case Reports JO - BMJ Case Reports DO - 10.1136/bcr-2018-228295 VL - 12 IS - 8 SP - e228295 AU - Tatiana Gonçalves AU - Lèlita Santos Y1 - 2019/08/01 UR - http://casereports.bmj.com/content/12/8/e228295.abstract N2 - Digital ulcers are one of the earliest and most disabling manifestations of systemic sclerosis (SSc). We report the clinical case of a female patient with SSc and severe digital ulcers, recurrent and refractory to the classic treatments to whom it was prescribed off-label macitentan with complete resolution of the condition. ER -