@article {Houcke229339, author = {Philip D Houck and Billy Jones and Rikin Patel and Greg Olsovsky}, title = {Pathophysiology of narrow complex dilated cardiomyopathy insight derived from the velocity equation: velocity = distance/time}, volume = {12}, number = {8}, elocation-id = {e229339}, year = {2019}, doi = {10.1136/bcr-2019-229339}, publisher = {BMJ Specialist Journals}, abstract = {The pathophysiology of narrow complex dilated cardiomyopathy is not defined, so therapeutic options are limited. By utilising the velocity equation, the pathophysiology of narrow complex cardiomyopathy allows above normal conduction propagation velocities. There are two pathophysiological theories that allow above normal conduction velocities and failure to capture the myocardium: (1)insulating fibres of the conduction system extending beyond the apex and (2) reduction of axon branching. A patient with narrow complex cardiomyopathy was subjected to graded increase in amplitude and pulse width pacing to overcome the failure of native conduction to capture the myocardium. Peak systolic strain maps demonstrated a progressive increase in apical contractility with increasing pulse width and amplitude. Ejection fraction improved from 17\% to 31\%. Understanding the pathophysiology of narrow complex cardiomyopathy leads to proposed therapies. One potential pacing therapy is multi-lead pacing at high amplitude and pulse width to capture myocardial cells not captured by native conduction.}, URL = {https://casereports.bmj.com/content/12/8/e229339}, eprint = {https://casereports.bmj.com/content/12/8/e229339.full.pdf}, journal = {BMJ Case Reports CP} }