RT Journal Article
SR Electronic
T1 Hypertensive urgency in nephrogenic diabetes insipidus with concomitant Hinman syndrome
JF BMJ Case Reports
JO BMJ Case Reports
FD BMJ Publishing Group Ltd
SP e229095
DO 10.1136/bcr-2018-229095
VO 12
IS 7
A1 Yu Guang Tan
A1 Daniel Wei Keong Chan
A1 Fabian Kok Peng Yap
A1 Te-Lu Yap
YR 2019
UL http://casereports.bmj.com/content/12/7/e229095.abstract
AB Diabetes insipidus is a syndrome characterised by the inability to conserve water or concentrate urine, leading to excessive excretion of urine. In congenital nephrogenic diabetes insipidus (CNDI), common presentations include failure to thrive, polydipsia, polyuria and dehydration. The long trajectory of the disease, coupled with psycho-behavioural changes as a child grows, can precipitate a period of non-adherence despite initial optimal control, especially in the adolescent age group. Social inconvenience of repeated voiding and nocturnal disturbances can lead to adapted urine holding behaviour, also known as non-neurogenic neurogenic bladder (Hinman syndrome). Anatomical changes in the urinary system, such as bladder trabeculation and hydroureteronephrosis, can subsequently give rise to functional renal impairment. We present a case of CNDI with concomitant Hinman syndrome, resulting in acute renal impairment and hypertensive emergency. We aim to raise awareness of the association between these two entities.