RT Journal Article
SR Electronic
T1 Severe proximal myopathy secondary to Hashimoto’s thyroiditis
JF BMJ Case Reports
JO BMJ Case Reports
FD BMJ Publishing Group Ltd
SP e230427
DO 10.1136/bcr-2019-230427
VO 12
IS 7
A1 William Jervis
A1 Najeeb Shah
A1 Shiva Kumar Mongolu
A1 Thozhukat Sathyapalan
YR 2019
UL http://casereports.bmj.com/content/12/7/e230427.abstract
AB Muscular symptoms in hypothyroidism are common, including myalgia, fatigue and cramps; however, a significantly raised creatine kinase and muscle weakness are rare. Differential diagnosis of patients presenting with muscle weakness and a raised creatine kinase is wide, and hypothyroidism is rarely considered. We report this case of a 30-year-old female presenting with proximal muscle weakness as her primary symptom, hypothyroid symptoms of 3-month duration and a significantly raised creatine kinase. After ruling out other causes of a raised creatine kinase, thyroxine replacement was commenced, which led to complete resolution of her proximal weakness, myalgia and normalisation of creatine kinase level. This case illustrates severe proximal myopathy can be secondary to hypothyroidism, symptoms can resolve with thyroxine replacement and emphasises the importance of measuring thyroid function in patients with proximal weakness/myalgia and a significantly raised creatine kinase.