TY - JOUR T1 - Seizures, renal failure and acute respiratory failure: not your typical case of Henoch-Schonlein purpura JF - BMJ Case Reports JO - BMJ Case Reports DO - 10.1136/bcr-2019-229939 VL - 12 IS - 7 SP - e229939 AU - Subhasish Bose AU - Samata Pathireddy AU - Krishna M Baradhi AU - Narothama Reddy Aeddula Y1 - 2019/07/01 UR - http://casereports.bmj.com/content/12/7/e229939.abstract N2 - A 30-year-old Caucasian woman with no prior medical history presented with pedal oedema, arthralgias and abdominal pain with diarrhoea, following a respiratory infection. She had mild abdominal tenderness along with a purpuric rash on the extremities and was anaemic. Following initial workup for anaemia and rash, her condition deteriorated with renal impairment, respiratory failure and seizures necessitating ventilatory support, dialysis and steroids. Serologies were negative, and skin biopsy showed leucocytoclastic vasculitis without vascular IgA deposition, and renal biopsy showed subendothelial, mesangial deposits of IgA with C3 indicative of Henoch-Schonlein purpura (HSP). She was treated with steroids, haemodialysis and on 6-month follow-up recovered renal function. We present the case to illustrate that HSP, though rare in adults, can present with multiorgan failure, with renal, pulmonary and central nervous system involvement, and the need for early diagnosis and prompt treatment for rapid clinical recovery. ER -