RT Journal Article
SR Electronic
T1 Acute splenic infarction presenting as an unusual manifestation of essential thrombocythaemia with normal platelet count
JF BMJ Case Reports
JO BMJ Case Reports
FD BMJ Publishing Group Ltd
SP e229387
DO 10.1136/bcr-2019-229387
VO 12
IS 7
A1 Katsuyuki Yoshida
A1 Ibuki Kurihara
A1 Takahiko Fukuchi
A1 Hitoshi Sugawara
YR 2019
UL http://casereports.bmj.com/content/12/7/e229387.abstract
AB Essential thrombocythaemia (ET) is characterised by elevated platelet count by a clonal stem cell disorder of megakaryocytes. Although thrombosis is a common complication of ET, splenic infarction (SI) is extremely rare. Here, we present the case of a 31-year-old Japanese man who presented with sudden-onset severe pain at the left hypochondrium on the day before admission. Enhanced abdominal CT revealed SI. The laboratory test results revealed a normal platelet count (439×109/L). Subsequently, the patient was diagnosed with ET because the platelet count gradually increased to 50.0×104/μL, and JAK2 V617F mutation was identified. Accordingly, low-dose aspirin was initiated, and no thrombotic episode occurred. Nevertheless, 6 months postdischarge, the platelet count gradually increased to >650 × 109/L, and anagrelide was initiated. This case demonstrates an unusual complication of acute SI due to ET under the rare situation of the normal platelet count.