TY - JOUR T1 - Temozolomide-induced aplastic anaemia and incidental low-grade B-cell non-Hodgkin lymphoma in a geriatric patient with glioblastoma multiforme JF - BMJ Case Reports JO - BMJ Case Reports DO - 10.1136/bcr-2018-228803 VL - 12 IS - 6 SP - e228803 AU - Felipe Batalini AU - Matthew R Kaufmann AU - Gabriel Francisco Aleixo AU - Reed Drews Y1 - 2019/06/01 UR - http://casereports.bmj.com/content/12/6/e228803.abstract N2 - Glioblastoma multiforme is an astrocyte-derived tumour representing the most aggressive primary brain malignancy. The median overall survival is 10–12 months, but it drops to 3–8.5 months for the cohort with more than 65 years old, which account to half of all patients. Initial management in this patient population aims to balance overall patient survival and quality of life with the inherent risks of treatment intervention, which include maximal safe tumour resection, radiation and temozolomide (TMZ) chemotherapy. This is accomplished through risk stratification as a function of patient age, functional status, comorbidities, tumour location and methylguanine methyltransferase promoter methylation status. We describe the care of a patient with prolonged febrile neutropaenia, with a rare but fatal complication from TMZ-induced idiosyncratic reaction, leading to aplastic anaemia and a provoking diagnosis of low-grade B-cell non-Hodgkin’s lymphoma. ER -