PT  - JOURNAL ARTICLE
AU  - Anson Snow
AU  - Charite Ricker
AU  - Gino K In
TI  - Two synchronous malignancies: nodular melanoma and renal cell carcinoma in a patient with an underlying germline <em>BRCA2</em> mutation
AID  - 10.1136/bcr-2018-227625
DP  - 2019 Jun 01
TA  - BMJ Case Reports
PG  - e227625
VI  - 12
IP  - 6
4099  - http://casereports.bmj.com/content/12/6/e227625.short
4100  - http://casereports.bmj.com/content/12/6/e227625.full
SO  - BMJ Case Reports2019 Jun 01; 12
AB  - Modernised genetic testing among patients with cancer has led to an increasing wealth of knowledge regarding cancer biology and aetiology. Furthermore, some germline mutations have the potential to direct therapeutic approaches as well. While BRCA1/2 mutations are well-established risk factors for breast and ovarian cancers, their impact on other cancers is less understood. We describe a patient with a germline BRCA2 mutation who developed synchronous melanoma and renal cell carcinoma, but responded well to treatment and is now cancer free.