TY - JOUR T1 - Signet ring cell carcinoma of the rectum: atypical metastatic presentation JF - BMJ Case Reports JO - BMJ Case Reports DO - 10.1136/bcr-2018-229135 VL - 12 IS - 4 SP - e229135 AU - Mariana Morales-Cruz AU - Noel Salgado-Nesme AU - Alicia Maybi Trolle-Silva AU - Jorge Humberto Rodríguez-Quintero Y1 - 2019/04/01 UR - http://casereports.bmj.com/content/12/4/e229135.abstract N2 - Colorectal cancer is the third most common cancer in the world and the fourth most common cause of death related to cancer. Signet ring cell carcinoma represents an uncommon histological type for rectal cancer with less than 1% of all rectal neoplasms. It usually behaves aggressively and has an inferior prognosis. We present the case of a young man diagnosed with signet ring cell rectal carcinoma. He underwent neoadjuvant therapy with partial response, had surgery with curative intent and showed local recurrence after only 3 months. Disease progression happened only weeks after recurrence with metastasis to vertebrae, extraocular muscles, bone marrow and skin. He is currently receiving palliative chemotherapy. ER -