RT Journal Article SR Electronic T1 Man with epigastric pain and persistently elevated serum lipase JF BMJ Case Reports JO BMJ Case Reports FD BMJ Publishing Group Ltd SP e229208 DO 10.1136/bcr-2019-229208 VO 12 IS 4 A1 Caroline Annette Erika Bachmeier A1 Adam Morton YR 2019 UL http://casereports.bmj.com/content/12/4/e229208.abstract AB Serum lipase and amylase are commonly requested in individuals presenting with abdominal pain for investigation of acute pancreatitis. Pancreatic hyperenzymaemia is not specific for acute pancreatitis, occurring in many other pancreatic and non-pancreatic conditions. Where persistent elevation of serum lipase and amylase occurs in the absence of a diagnosed cause or evidence of laboratory assay interference, ongoing radiological assessment for pancreatic disease is required for 24 months before a diagnosis of benign pancreatic hyperenzymaemia can be made. We report a case of a 71-year-old man with epigastric pain and elevated serum lipase levels. He was extensively investigated, but no pancreatic disease was detected. He is asymptomatic, but serum lipase levels remain elevated 18 months after his initial presentation.