PT - JOURNAL ARTICLE AU - Caroline Annette Erika Bachmeier AU - Adam Morton TI - Man with epigastric pain and persistently elevated serum lipase AID - 10.1136/bcr-2019-229208 DP - 2019 Apr 01 TA - BMJ Case Reports PG - e229208 VI - 12 IP - 4 4099 - http://casereports.bmj.com/content/12/4/e229208.short 4100 - http://casereports.bmj.com/content/12/4/e229208.full SO - BMJ Case Reports2019 Apr 01; 12 AB - Serum lipase and amylase are commonly requested in individuals presenting with abdominal pain for investigation of acute pancreatitis. Pancreatic hyperenzymaemia is not specific for acute pancreatitis, occurring in many other pancreatic and non-pancreatic conditions. Where persistent elevation of serum lipase and amylase occurs in the absence of a diagnosed cause or evidence of laboratory assay interference, ongoing radiological assessment for pancreatic disease is required for 24 months before a diagnosis of benign pancreatic hyperenzymaemia can be made. We report a case of a 71-year-old man with epigastric pain and elevated serum lipase levels. He was extensively investigated, but no pancreatic disease was detected. He is asymptomatic, but serum lipase levels remain elevated 18 months after his initial presentation.