PT - JOURNAL ARTICLE AU - Jamia Ahmad AU - Md Jahidul Hasan AU - Ahmad Mursel Anam AU - Dipesh Kumar Barua TI - Donepezil: an unusual therapy for acute diphenhydramine overdose AID - 10.1136/bcr-2018-226836 DP - 2019 Mar 01 TA - BMJ Case Reports PG - e226836 VI - 12 IP - 3 4099 - http://casereports.bmj.com/content/12/3/e226836.short 4100 - http://casereports.bmj.com/content/12/3/e226836.full SO - BMJ Case Reports2019 Mar 01; 12 AB - An elderly man presented with the history of diphenhydramine hydrochloride overdose as a suicidal attempt. At presentation, he was in an acute confusional state with several anticholinergic features and had to be managed in intensive care unit. As an antidote for diphenhydramine hydrochloride, donepezil was used instead of physostigmine due to the unavailability of physostigmine in Bangladesh. The patient improved within the next 24 hours; his level of consciousness improved and the anticholinergic features regressed.