@article {Rhoadese226755, author = {Ruben Rhoades and Jerald Gong and Neil Palmisiano and Onder Alpdogan}, title = {Primary central nervous system plasmablastic lymphoma in an HIV-positive patient}, volume = {12}, number = {3}, elocation-id = {e226755}, year = {2019}, doi = {10.1136/bcr-2018-226755}, publisher = {BMJ Specialist Journals}, abstract = {Plasmablastic lymphoma (PBL) is a rare subtype of diffuse large B-cell lymphoma, highly associated with HIV and Epstein-Barr virus (EBV) infections. It commonly presents in extranodal sites, often an oral mass, but reports of primary central nervous system PBL (PCNSPBL) are exceedingly rare. Here, we report on a 33-year-old man with newly diagnosed HIV infection who presented with acute-onset unilateral visual disturbance and was found to have biopsy-proven PCNSPBL. The neoplastic cells displayed a plasmacytoid appearance, with the expression of CD38 and CD138, and were positive for EBV by in situ hybridisation for EBV-encoded RNA. Systemic workup revealed the presence of Kaposi sarcoma, but no evidence of lymphoma. He is currently being treated with high-dose methotrexate, as well as antiretroviral therapy for his HIV infection, and has achieved a complete response.}, URL = {https://casereports.bmj.com/content/12/3/e226755}, eprint = {https://casereports.bmj.com/content/12/3/e226755.full.pdf}, journal = {BMJ Case Reports CP} }