PT  - JOURNAL ARTICLE
AU  - Chang, Jeremy
AU  - Tran, Jeffrey
AU  - Kamel, Dina
AU  - Basu, Arnab
TI  - Nivolumab-induced hypophysitis leading to hypopituitarism and secondary empty sella syndrome in a patient with non-small cell lung cancer
AID  - 10.1136/bcr-2018-228135
DP  - 2019 Mar 01
TA  - BMJ Case Reports
PG  - e228135
VI  - 12
IP  - 3
4099  - http://casereports.bmj.com/content/12/3/e228135.short
4100  - http://casereports.bmj.com/content/12/3/e228135.full
SO  - BMJ Case Reports2019 Mar 01; 12
AB  - We describe the clinical course of a 64-year-old woman with stage IVa lung adenocarcinoma who presented with over 1 month of fatigue, unintentional weight loss and emesis. She initiated treatment with nivolumab immunotherapy 1 year prior and had been tolerating the treatment well. A comprehensive workup revealed multiple endocrinological abnormalities consistent with hypophysitis leading to hypopituitarism in the form of central adrenal insufficiency and hypogonadism as well as a partially empty sella on imaging. This case demonstrates that while receiving novel forms of treatment such as immunotherapy, patients should be monitored closely for a wide range of adverse effects.